China H&Z® Indometacin Factory
Indometacin CAS:53-86-1
Indometacin Chemical Properties
MF:C19H16ClNO4
MW:357.79
Melting point:155-162°C
Boiling point:499.4±45.0°C(Predicted)
Density:1.2135 (rough estimate)
solubility :ethanol: 50 mg/mL, clear, yellow-green
Indometacin Specification:
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TestsItems |
Requirements |
Results |
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Characters |
A white pale yellow crystalline powder, Odourless or almost odourless. |
Complies |
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Solubility |
Practically insoluble in water,spaeingly soluble in wthanol(96%) |
Complies |
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Identification |
m.p. |
158-162℃ |
158-161℃ |
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IR |
The IR of sample which to be examined corresponding to the reference indometacin RS. |
Complies |
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Heavy metals |
≤20ppm |
Complies |
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Loss on drying |
≤0.5% |
0.08% |
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Sulphated ash |
≤0.10% |
0.09% |
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Related substances |
Single unkownn Impurity≤0.10% |
0.025% |
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Total Impurity≤0.3% |
0.08% |
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Microbial limits |
Aerobic bacteria per 1g must not exceed the total number of103cfu. |
<10cfu |
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Fungi and yeast per 1g must not exceed 102cfu |
<10cfu |
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Escherichia coli per 1g must not be detected |
Not detected |
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Assay |
98.0-102.0% On the dried substance |
100.2% |
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Conclusion:The product was tested according to EP9.0,the results meet the requirements |
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Indometacin Function:
H&Z® Indometacin is anti-inflammatory, antipyretic effect is obvious, mainly used for salicylic acid drugs not easy to tolerate or curative effect is not significant rheumatic joint inflammation, ankylosing spondylitis, osteoarthritis and so on.
Indometacin Application:
The anti-inflammatory effect of indomethacin is stronger than that of butazone and hydrocortisone, and the combined application of indomethacin can reduce the dosage and side effects of the latter.
The antipyretic effect was 10 times that of aminopyrine. But the analgesic effect is weak, only has the obvious analgesic effect to the inflammatory pain.
Gastrointestinal absorption is rapid and complete after oral administration in monogastric animals. The plasma protein binding rate reached 90% at the peak of 1.5 ~ 2h. It is conjugated with glucuronic acid in the liver and excreted by the kidneys.
Some of them enter the intestines with bile and are reabsorbed, while others are discharged by feces. For postoperative trauma, arthritis, tenosynovitis, muscle injury and other inflammatory pain.
